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GLOBAL MICRO-STRUCTURAL WHITE MATTER ALTERATIONS IN THE FIRST-EPISODE ANTIPSYCHOTIC-NAIVE SCHIZOPHRENIA PATIENTS.
The patients were clinically stable but experiencing symptoms or adverse events sufficient to warrant a change in antipsychotic therapy.
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Lack of efficacy and side effects with APDs lead to poor compliance in schizophrenia therapy.
Electroconvulsive therapy can be useful in some situations.
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Numerous studies of genotype-phenotype relationships in yeast, flies and mice show that individual gene effects are critically modulated by other genes in epistatic networks.
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There were no significant differences among the groups in the incidence of extrapyramidal side effects, akathisia, or movement disorders as reflected by rating-scale measures of severity.
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Each patient, or the authorized legal representative, signed an informed consent document that fully explained the risks and benefits of study participation.
Fat-mass and obesity-associated gene polymorphisms and weight gain after risperidone treatment in first episode schizophrenia.
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SMI are less likely to receive standard levels of care for most of these diseases.
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He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc.
Some guidelines, such as the United Kingdom NICR guidelines, advise against the use of valproate in women of childbearing age, due to the high frequency of unplanned pregnancies in women with and even without bipolar disorder, and the relatively high teratogenicity of the compound, but this may be going too far, and could prove impractical.
Behaviour research and therapy.
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Behavioral and psychopharmacological treatments have been the mainstay of treatments for aggression in children and adolescents with autism.
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In addition to the 5 symptom domain areas identified in the first diagnostic criterion, assessment of cognition, depression, and mania symptom domains is vital for distinguishing between schizophrenia and other psychotic disorders.
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In line with this finding, Zyprexa patients saw significant increases in cholesterol and other blood fats, while Geodon patients lipid profiles remained stable.
Methods: The model of intervention services to be implemented was fully described in a manual developed as part of an earlier phase of work on this reform initiative.
The original manufacturer uses a brand name whereas a generic drug is usually called by the name of the active ingredient.
These relationships were not observed in younger schizophrenia or healthy participants.
One approach has used indicators of pre-morbid and current IQ to divide people with schizophrenia (Sz) into cognitive subgroups.
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In many cases, this would lead to the conclusion that other drugs should be tried first.
Chi-square test, independent samples t-test, and one-bivariate correlations analysis were used for data analysis.
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The degree of neuromuscular block is assessed using nerve stimulation, where two electrodes impose a pulse of current on a peripheral nerve (e.
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Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, MA, USA; 12.
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Aggression is evidenced in adolescents with Autism Spectrum Disorders.
Serotonin re-uptake inhibitors, such as sertraline, are the medication of choice in post-traumatic stress disorder.
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Methods: Using a multiplex platform we evaluated 117 plasma analytes involving immunity and hormones, and oxidative stress in 72 clinical high risk (35 who subsequently developed psychosis) and 35 unaffected subjects.
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Paranoid personality disorder may be first apparent in childhood and adolescence with solitariness, poor peer relationships, social anxiety, underachievement in school, hypersensitivity, and peculiar thoughts and language.
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Decreases in triglycerides in the pre-switch risperidone group (17 % at 6 weeks; 16 % at 58 weeks) were also clinically relevant.
The method comprises investigation of therapeutic substance release from the drug form with the help of apparatus Il (blade apparatus) with the rotational speed of 75 rpm.
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Results: In unmedicated patients compared to controls we found increased resting state functional connectivity in the executive control network, salience network, and dorsal attention network, but not in the default mode network.
Results provide initial support for a positive association between trait mindfulness and emotion regulation.
In search of innovative therapeutics for neuropsychiatric disorders: The case of neurodegenerative diseases.
Simple phobia is the most common anxiety disorder, with up to 49% of people reporting an unreasonably strong fear and 25% of those people meeting criteria for simple phobia.
In Bipolar I Disorder family, twin and adoption studies suggest genetic factors.
The submission included data from a new Phase 3 trial and several Phase 1 drug-drug interaction studies.
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Ziprasidone is indicated for the treatment of schizophrenia, as monotherapy for the acute treatment of bipolar manic or mixed episodes, and as an adjunct to lithium or valproate for the maintenance treatment of bipolar disorder.
G5), blunted affect (N1), social withdrawal (N4), and lack of spontaneity (N6).
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For dysthymia, paroxetine improved mental health functioning vs placebo among patients whose baseline functioning was high or intermediate.
The side-effect profile is comparable to that of oral olanzapine.
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For example, chlomipramine, an antidepressant known to be associated with weight gain and increased food intake in humans, decreases food intake in animals ().
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Some authors suggested that risperidone could exacerbate or induce mania, presumably through antidepressant effects but further trials - confirmed that risk to be very low.
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Initiate cognitive-behavioral therapy along with medication to significantly increase response rates.
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The remaining studies were screened for relevance and categorized by a medical researcher; 693 were rejected as not relating to the treatment of eating disorders.
About 5% of patients receiving long-term lithium therapy have been found to have hypercalcemia.
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In addition, we have carried out several studies which have examined the role of gamma-band oscillations and event-related fields (ERFs) in sensory processing in schizophrenia.
In teaching the kids, positive reinforcement is used.
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SCZ patients and animal models under the treatment with the same antipsychotics are currently ongoing in our laboratory and they might bring some important information regarding the potential of this specific enzyme activity measurements as a biomarker of pharmacological interventions and treatment follow-up.
Lithium has been widely used since 1970 for treating bipolar disorder despite a number of side effects, a narrow therapeutic window, and limited effectiveness in some patients.
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Cognitive functioning was assessed using Chinese version of MATRICS Consensus Cognition Battery (MCCB).
Our approach models FNC matrices computed on successive windowed segments of network timecourses (wFNCs) as weighted sums of maximally temporally independent basis connectivity patterns (BCPs).
In a set of clinical trials lasting 4 to 6 weeks testing Geodon in the treatment of schizophrenia, there was more weight gain in the Geodon group than in the placebo (sugar pill) group.
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Outpatients suffering from MDD will be treated with either ziprasidone or placebo for 12 weeks.
Conclusion: Internalized stigma was associated with socioaffective constructs among HRP individuals, and reducing stigma might ameliorate anxiety and depression.
High extraversion is seen in Histrionic and Narcissistic Personality Disorders.
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Before taking ziprasidone, tell your doctor if you regularly use any other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety).
These medications offer the advantage of improved efficacy in the treatment of positive and negative symptoms of psychosis, as well as a better side effect profile over the older agents (fewer extra pyramidal side effects and decreased propensity to cause increased prolactin levels).
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Ziprasidone had no effect on serum prolactin in rats in a 5-week dietary study at the doses that were used in the carcinogenicity study.
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Results: Mann-Whitney U-tests revealed group differences in SSS effects.
However, it has been proposed that this drug's efficacy in schizophrenia is mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) antagonism.
Our study assesses anticipatory and consummatory pleasure using two new measures.
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Olanzapine too, but the risk side is too great to justify this medication unless symptoms are terrible or a lot of other things have been tried.
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Bipolar affective disorder, or manic-depressive illness (MDI), is a common, severe, and persistent mental illness.
Note: Alcoholics and drug addicts are more violent, on average, than individuals with schizophrenia.
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Additive QTc-prolonging effects increases risk of cardiac arrhythmias.
Such medications can interact with drugs used to treat bipolar disorder or increase side effects.
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Two-group comparisons were performed by Student's t test.
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Methods: Fifteen schizophrenia patients and 21 healthy controls, matched for gender and age, participated in this study.
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We conducted the first large-scale MRI investigation of first-episode psychosis (FEP) in such large urban center using a longitudinal design.
Therapy that includes the entire family is important.
For instance, a youngster may have little trouble learning to read but exhibit extremely poor social interaction.
The differential diagnosis of schizoaffective disorder.
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Methods: Indian patients with schizophrenia (DSM IV criteria) were assessed using the Diagnostic Interview for Genetic Studies (DIGS) and the Independent Living Skills Scale (ILSS); HSV-1 exposure was assessed with serological IgG antibody assays.
Systems of care serving persons with schizophrenia should include a program of assertive community treatment (ACT).
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Assess for improvement or change of the core symptoms of depression through a clinical interview or the use of a standardized rating scale to determine changes in the severity of depression.
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Geodon comprises of active ingredient Ziprasidone hydrochloride monohydrate and inactive ingredients lactose, magnesium stearate and pregelatinised maize starch.
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It has some alpha-adrenergic and anticholinergic effects.
The present data strongly support the critical role of neurocognitive factors, such as episodic memory, in recovery of work functioning in schizophrenia.
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