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Valturna patients received concurrent therapy with diabetic medications.
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Monitor white blood cell counts periodically in patients with collagen vascular disease or those who are taking a drug known to affect white blood cells or the immune response, particularly when there is impaired renal function.
Effect of the VKORC1 D36Y variant on warfarin dose requirement and pharmacogenetic dose prediction.
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Plasma concentrations of perindopril and perindoprilat in patients older than 70 y are approximately twice those observed in younger patients; renal excretion of perindoprilat decreases.
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The patients selected were not on any ACE-inhibiting medication at the time of recruitment.
ACE inhibitors reduce the activity of the renin-angiotensin-aldosterone system (RAAS) as the primary etiologic (causal) event in the development of hypertension in people with diabetes mellitus, as part of the insulin-resistance syndrome or as a manifestation of renal disease.
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Stabilisation of the pharmaceutical preparation by use of a new salt of perindopril (arginine salt of perindopril) is described in the aforesaid patent application.
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Perindopril has been studied in relatively few black patients, usually a low-renin population, and the average response of diastolic blood pressure to perindopril was about half the response seen in nonblack patients, a finding consistent with previous experience of other ACE inhibitors.
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