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On-treatment platelet reactivity and response to single or combined antiplatelet therapy have been evaluated with several small studies demonstrating platelet reactivity, which correlated with cardiovascular morbidity.

The relative difference in antiplatelet response between genotype groups varies across studies depending on the method used to evaluate response, but is typically greater than 30%.

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Clopidogrel has been shown to benefit patients with documented atherosclerosis (recent myocardial infarction, recent stroke, or established peripheral arterial disease), patients who have undergone percutaneous coronary intervention, and patients with unstable angina or myocardial infarction that is not associated with ST-segment elevation.

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Due to the potential for internal bleeding I was told by the hospital endoscopy department that I must stop taking Clopidogrel seven days before the procedure which I did.

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Investigating the protective effects of aged garlic extract on cyclosporin-induced nephrotoxicity in rats.

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Beta blockers should not be administered to patients with ACS with a recent history of cocaine or methamphetamine use who demonstrate signs of acute intoxication due to the risk of potentiating coronary spasm.

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The Medline English-language database was searched from January 1970 to January 2010 using multiple keywords and standardized terminology, where applicable, as outlined in Appendix S1.

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Contributors: IJD conceived the study, analysed the data, interpreted the results, and wrote the paper.

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In CAPRIE, which compared clopidogrel to aspirin, pruritus was more frequently reported in those taking clopidogrel.

ST-elevation myocardial infarction and the overall population of patients with acute coronary syndromes, and to preserve the statistical power to detect a difference between the two treatment groups, we used a closed testing procedure.

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The Antithrombotic Trialists' Collaboration reported a proportional increase in the odds of major bleeding of 60% with the use of antiplatelet agents (largely aspirin), as compared with placebo.

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Only events that were confirmed by the adjudication committee and that occurred during treatment or within 28 days after the discontinuation of treatment were included in the analysis.

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