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When medications are required, second-generation antipsychotics, preferred by many psychiatrists over first-generation antipsychotics for long-term management of psychiatric illnesses, have also become increasingly used in the acute setting for management of agitation.

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Wasn't this a significant side effect claim that led to prescription advice altering in a number of juristictions?

Test batteries such as the PACE (Personal Assessment and Crisis Evaluation Clinic) and COPS (Criteria of Prodromal Syndromes), which measure low level psychotic symptoms, and others focused on cognitive disturbances (Basic symptoms"), are used to evaluate people with early, low level symptoms of psychosis.

Only children who met the inclusion criteria for the CGI-S scale (according to an experienced clinician) and the score on the Irritability subscale (based on the parent's or primary caretaker's rating) at base line as well as at the time of screening were eligible for randomization.

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Antipsychotics typically worsen symptoms in people who suffer from depersonalisation disorder.

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