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Physicians and caretakers of persons with dementia should try to address symptoms including agitation, aggression, apathy, anxiety, depression, irritability, and psychosis with alternative treatments whenever antipsychotic use can be replaced or reduced.

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People with mental retardation are each unique, with very different needs and abilities, even if they have the same IQ.

The chance that this will happen or that it will become permanent is greater in those who take clozapine in high doses or for a long time.

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Bupropion (Wellbutrin) does not have enough evidence yet to verify its effectiveness for social anxiety disorder.

Any side effects related to clozapine should be reported to the FDA MedWatch program, the FDA urged.

Carbamazepine (Tegretol) can cause potentially fatal hematological disorders.

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Index treatment discontinuation was defined as any gap of more than 30 days in prescription of the newly initiated antipsychotic medication.

Selective Serotonin Uptake Inhibitors (SSRI) A more common form of antidepressant medication used to treat depression or others disorders.

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CYP2C9, 1A2, and 2D6, with low K M values, showed a more steady contribution, ranging from 5 to 15% at therapeutic clozapine concentrations.

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Use nonjudgmental and realistic comments.

Displacement is a defense mechanism that refers ideas and feelings to something or someone not responsible for them (eg, a husband comes home and yells at his wife because of a bad day at work).

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BACKGROUND: Borderline personality disorder (BPD) is a serious mental disorder that is difficult to treat.

Some cognitive features may reflect global such as memory loss, while others may be related to particular issues and experiences.

Higher relapse rates are seen when medication is discontinued.

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Depression in schizophrenia requires essentially the same treatment strategies as depression without schizophrenia, although it may make sense to switch from a high-potency conventional antipsychotic to a low-potency atypical drug such as quetiapine, which is now licensed for bipolar depression.

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Safety and efficacy have not been established for children up to 16 years of age.

Focus on developing services that are integrated and comprehensive, where treatment is flexibly organized around a cross-trained team that is able to offer clinical intervention for both mental health and substance use disorders.

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