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THE EFFECT OF VALPROATE ON TESTICULAR DEVELOPMENT AND ON SPERM PRODUCTION AND FERTILITY IN HUMANS IS UNKNOWN.
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Antiepileptic drugs (AEDs), including Depakote, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication.
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It is not clear whether these events indicate additional risk or whether they result from preexisting medical illness and concomitant medication use among these patients.
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Intolerance was the primary reason for discontinuation in the DEPAKOTE-treated patients (6%), compared to 1% of placebo-treated patients.
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May 12, 2011, I was diagnosed by this same doctor to have “irreversible pheriphal neuropathy” due to long term use of Dilantin.
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